# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20150706: Eukaryota_PTN000460428 is found in Prp19 complex (GO:0000974) 
20150706: Eukaryota_PTN000460428 co-localizes with DNA replication factor A complex (GO:0005662) 
20150706: Eukaryota_PTN000460428 is found in Cul4-RING E3 ubiquitin ligase complex (GO:0080008) 
20150706: Eukaryota_PTN000460428 is found in catalytic step 2 spliceosome (GO:0071013) 
20150706: Eukaryota_PTN000460428 is found in precatalytic spliceosome (GO:0071011) 

# biological_process
20150706: Eukaryota_PTN000460428 participates in mRNA splicing, via spliceosome (GO:0000398) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family contains PRP46 (S. cerevisiae), aka PLRG1 (vertebrates), Tango4 (D. melanogaster), PRL1 & PRL2 (A. thaliana). This protein has been shown to be part of the Prp19 complex involved in assembly of the spliceosome, as well as subsequent conformational rearrangements to produce catalytic complexes, and dissasembly. It has also been shown to be part of a U-box-containing E3 ubiquitin ligase, along with PRP19,  CDC5L, and SPF27 (PMID:24332808, PMID:18223036).

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).