# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140922: Eukaryota_PTN000457905 has function snoRNA binding (GO:0030515) 

# cellular_component
20140922: Eukaryota_PTN000457905 is found in Pwp2p-containing subcomplex of 90S preribosome (GO:0034388) 
20140922: Eukaryota_PTN000457905 is found in small-subunit processome (GO:0032040) 

# biological_process
20140922: Eukaryota_PTN000457905 participates in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) (GO:0000462) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
challenge TAS annotations for human TBL3 from PMID:8307582
This family is comprised of two protein familes that contain WD40 repeat domains. However, it has a duplication node at the top and it is possible that the two clades should be separated into separate families, as there is only the minimal similarity, presumably related to containing a WD40 repeat domain, but no obviously conserved function or process between the two clades.
UTP13, aka TBL3 clade
================
This clade comprises the UTP13, aka TBL3, subunits of the ribosomal Small Subunit Processome, also called the SSU Processome, a large complex which is involved in the initial cleavages of the primary rRNA transcript to separate the small ribosomal subunit (SSU) rRNA from the remainder of the transcript and the biogenesis of the small ribosomal subunit.
The SSU processome was originally identified and characterized from S. cerevisiae (Dragon et al. 2002, PMID:12068309; Gallagher et al. 2004, PMID:15489292; Bernstein et al. 2004, PMID:15590835; and reviewed in Phipps et al. 2011, PMID:21318072). As of September 2014, it has begun to be characterized experimentally from other species such as human (Turner et al. 2012, PMID:22418842; Sato et al. 2013, PMID:24219289; and Hu et al. 2011, PMID:21078665), zebrafish (Wilkins et al. 2013, PMID:24147052), and mouse (Gallenberger et al. 2011, PMID:21051332).
The UTP13, aka TBL3, subunit is a confirmed subunit of the SSU processome, and specifically part of the UtpB, aka Pwp2-containing, subcomplex (Phipps et al. 2011, PMID:21318072).
Feng et al. 2013 (PMID:24214024) performed an extensive computational analysis from 77 completely sequenced eukaryotic genomes, including representatives of the five eukaryotic supergroups: Opisthokonts, Amoebozoa, Plantae, Excavates, and Chromalveolates, and compared these to sequences from both prokaryotic and Archaeal species for all 51 confirmed and 26 likely SSU processome subunits in S. cerevisiae as indicated in Phipps et al. 2011 (PMID:21318072). In addition, Srivastava et al. have identified SSU processome subunits in the parasitic protist Entamoeba histolytica (PMID:24631428).
UTP13, aka TBL3, is one of the 51 confirmed proteins of the S. cerevisiae SSU processome (Phipps et al. 2011, PMID:21318072)) and is highly conserved across the 77 eukaryotic species, as listed in Table 1 of Feng et al. 2013 (PMID:24214024). It is also found in the parasitic protist Entamoeba histolytica (Srivastava et al. 2014, PMID:24631428).
Annotation comments:
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There were experimental MF annotations for human TBL3 to "poly(A) RNA binding" (GO:0044822) from a high throughput study: PMID:22658674. Between the fact that these was a high throughput experiment, the fact that this protein is normally part of a large complex, and the fact that it is not clear that poly(A) RNA binding is biologically relevant, I have chosen not to propagate this MF annotation.
GNB1L clade
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Only the mouse protein Gnb1l has any annotations, but they don't allow any propagations.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).