# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160421: root_PTN000452136 has function oxidoreductase activity (GO:0016491) 20160421: root_PTN000452136 has function FAD binding (GO:0071949) 20160421: Eukaryota_PTN000452207 has function cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128) 20160421: Eukaryota_PTN001833449 has function cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128) 20160421: Eukaryota_PTN001291528 has function cytochrome-b5 reductase activity, acting on NAD(P)H (GO:0004128) 20160421: Viridiplantae_PTN000452381 has function nitrate reductase (NADH) activity (GO:0009703) 20160421: Bacteria _PTN000452442 has function 2 iron, 2 sulfur cluster binding (GO:0051537) 20160421: Proteobacteria_PTN000452445 has function ferredoxin-NADP+ reductase activity (GO:0004324) 20160421: Eukaryota_PTN000452195 has function nitrate reductase (NADPH) activity (GO:0050464) 20160421: Bacteria _PTN001064640 has function riboflavin reductase (NADH) activity (GO:0052875) 20160421: Bacteria _PTN001064640 has function riboflavin reductase (NADPH) activity (GO:0042602) # cellular_component 20160421: Eukaryota_PTN001833428 is found in mitochondrion (GO:0005739) 20160421: saccharomyceta_PTN000452173 is found in endoplasmic reticulum (GO:0005783) 20160421: saccharomyceta_PTN001064708 is found in mitochondrion (GO:0005739) 20160421: saccharomyceta_PTN001833481 is found in plasma membrane (GO:0005886) 20160421: Metazoa_PTN001833497 is found in endoplasmic reticulum (GO:0005783) 20160421: Metazoa_PTN001833502 is found in mitochondrion (GO:0005739) 20160421: Viridiplantae_PTN000452381 is found in cytosol (GO:0005829) 20160421: Magnoliophyta_PTN001456837 is found in plastid (GO:0009536) 20160421: Embryophyta_PTN001456826 is found in chloroplast (GO:0009507) 20160421: Pentapetalae_PTN001833628 is found in chloroplast (GO:0009507) 20160421: Bacteria _PTN000452442 is found in cytosol (GO:0005829) 20160421: Bacteria _PTN001064648 is found in cytosol (GO:0005829) 20160421: Eukaryota_PTN000452195 is found in cytosol (GO:0005829) 20160421: Eukaryota_PTN001456792 is found in mitochondrion (GO:0005739) 20160421: node_PTN001833756 is found in cytosol (GO:0005829) # biological_process 20160421: Dikarya_PTN001064729 participates in ergosterol biosynthetic process (GO:0006696) 20160421: Eukaryota_PTN001833449 participates in electron transport chain (GO:0022900) 20160421: saccharomyceta_PTN001064708 participates in mitochondrial membrane organization (GO:0007006) 20160421: Metazoa_PTN001833497 participates in generation of precursor metabolites and energy (GO:0006091) 20160421: Metazoa_PTN001833497 participates in superoxide metabolic process (GO:0006801) 20160421: Viridiplantae_PTN000452381 participates in nitrate assimilation (GO:0042128) 20160421: Viridiplantae_PTN000452381 participates in nitric oxide biosynthetic process (GO:0006809) 20160421: Eukaryota_PTN000452195 participates in nitrogen compound metabolic process (GO:0006807) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).