# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141114: Opisthokonta_PTN000447753 has function syntaxin binding (GO:0019905) 20141114: Opisthokonta_PTN000447753 has function SNAP receptor activity (GO:0005484) 20141114: Euteleostomi_PTN000447850 has function syntaxin-1 binding (GO:0017075) # cellular_component 20141114: Eukaryota_PTN000447752 is found in plasma membrane (GO:0005886) 20141114: Opisthokonta_PTN000447753 is found in SNARE complex (GO:0031201) 20141114: Euteleostomi_PTN000447850 is found in synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex (GO:0070032) # biological_process 20141114: Opisthokonta_PTN000447753 participates in exocytosis (GO:0006887) 20141114: Opisthokonta_PTN000447753 participates in vesicle fusion (GO:0006906) 20141114: node_PTN000447754 participates in synaptic vesicle fusion to presynaptic active zone membrane (GO:0031629) 20141114: node_PTN000447754 participates in synaptic vesicle priming (GO:0016082) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Although many SNARE proteins are also found in plant, they may perform different functions (PMID:17506694). Not quite sure if they are be annotated to SNAP because SNARE are mostly referred to those responsible for vesicle fusion in yeast and mammalian cells. Therefore, the term SNAP receptor activity was only propagated to Opisthokonta. Nov. 14, 2014 - HM # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).