# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 18 Nov 2015: redistribution of PTN000578060 from PTHR23228 to PTHR19303 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150327: Bilateria_PTN000577900 has function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227) # cellular_component # biological_process 20150327: Euteleostomi_PTN000578104 participates in negative regulation of transcription, DNA-templated (GO:0045892) 20150327: Bilateria_PTN000577900 participates in axon guidance (GO:0007411) 20150327: Bilateria_PTN000577900 participates in negative regulation of transcription, DNA-templated (GO:0045892) 20150327: Euteleostomi_PTN000578267 participates in negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter (GO:1900477) 20150327: Euteleostomi_PTN000578396 participates in negative regulation of transcription, DNA-templated (GO:0045892) 20150327: Bilateria_PTN001507803 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20150327: Bilateria_PTN001507803 participates in regulation of neurogenesis (GO:0050767) 20150327: Bilateria_PTN001507803 participates in myeloid cell differentiation (GO:0030099) 20150327: Euteleostomi_PTN000578060 participates in type 2 immune response (GO:0042092) 20150327: Euteleostomi_PTN000578060 participates in regulation of inflammatory response (GO:0050727) 20150327: Euteleostomi_PTN000578060 participates in regulation of cell proliferation (GO:0042127) 20150327: Theria _PTN000148113 participates in positive regulation of gene expression (GO:0010628) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Most of the characterized proteins are transcription repressors. However, some are described as activators and many are not characterized, so I did not propagate the negative regulation to the root. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).