# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
16 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150810: Euteleostomi_PTN000445681 has function calcium channel regulator activity (GO:0005246) 

# cellular_component
20150810: Opisthokonta_PTN001060286 is found in integral component of plasma membrane (GO:0005887) 
20150810: Tetrapoda_PTN000445299 is found in endomembrane system (GO:0012505) 

# biological_process
20150810: Opisthokonta_PTN001060286 participates in cell surface receptor signaling pathway (GO:0007166) 
20150810: Euteleostomi_PTN000445681 participates in regulation of calcium ion transmembrane transport (GO:1903169) 
20150810: Tetrapoda_PTN000445299 participates in positive regulation of endocytosis (GO:0045807) 
20150810: Tetrapoda_PTN000445299 participates in cell adhesion (GO:0007155) 
20150810: Tetrapoda_PTN000445299 participates in cell migration (GO:0016477) 
20150810: Boreoeutheria_PTN000445003 participates in paranodal junction assembly (GO:0030913) 
20150810: Boreoeutheria_PTN000445003 participates in cell adhesion (GO:0007155) 
20150810: Boreoeutheria_PTN000445003 participates in fusion of sperm to egg plasma membrane (GO:0007342) 
20150810: Metazoa_PTN001830442 participates in establishment of protein localization to plasma membrane (GO:0090002) 
20150810: Metazoa_PTN001830442 participates in positive regulation of Notch signaling pathway (GO:0045747) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).