# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151109: Euteleostomi_PTN001058839 has function protein kinase binding (GO:0019901) 20151109: Euteleostomi_PTN001058839 has function integrin binding (GO:0005178) 20151109: Euteleostomi_PTN001058839 has function GTPase activator activity (GO:0005096) 20151109: Euteleostomi_PTN001058839 has function GPI anchor binding (GO:0034235) # cellular_component 20151109: Euteleostomi_PTN001058839 is found in dendrite (GO:0030425) 20151109: Euteleostomi_PTN001058839 is found in membrane raft (GO:0045121) 20151109: Euteleostomi_PTN001058839 is found in anchored component of external side of plasma membrane (GO:0031362) 20151109: Euteleostomi_PTN001058839 is found in myelin sheath (GO:0043209) # biological_process 20151109: Euteleostomi_PTN001058839 participates in focal adhesion assembly (GO:0048041) 20151109: Euteleostomi_PTN001058839 participates in positive regulation of release of sequestered calcium ion into cytosol (GO:0051281) 20151109: Euteleostomi_PTN001058839 participates in negative regulation of cell migration (GO:0030336) 20151109: Euteleostomi_PTN001058839 participates in positive regulation of T cell activation (GO:0050870) 20151109: Euteleostomi_PTN001058839 participates in negative regulation of protein kinase activity (GO:0006469) 20151109: Euteleostomi_PTN001058839 participates in T cell receptor signaling pathway (GO:0050852) 20151109: Euteleostomi_PTN001058839 participates in angiogenesis (GO:0001525) 20151109: Euteleostomi_PTN001058839 participates in negative regulation of axonogenesis (GO:0050771) 20151109: Euteleostomi_PTN001058839 participates in cytoskeleton organization (GO:0007010) 20151109: Euteleostomi_PTN001058839 participates in retinal cone cell development (GO:0046549) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).