# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141124: node_PTN000439006 has function phospholipid binding (GO:0005543) 20141124: node_PTN000439006 has function cholesterol transporter activity (GO:0017127) 20141124: node_PTN000439006 has function cholesterol binding (GO:0015485) 20141124: node_PTN000439006 has function phosphatidylcholine-sterol O-acyltransferase activator activity (GO:0060228) 20141124: Euteleostomi_PTN000439034 has function phosphatidylcholine binding (GO:0031210) 20141124: Tetrapoda_PTN000439036 has function high-density lipoprotein particle receptor binding (GO:0070653) 20141124: Euteleostomi_PTN000439007 has function low-density lipoprotein particle receptor binding (GO:0050750) 20141124: Euteleostomi_PTN000439007 has function beta-amyloid binding (GO:0001540) 20141124: Euteleostomi_PTN000439007 has function very-low-density lipoprotein particle receptor binding (GO:0070326) # cellular_component 20141124: node_PTN000439006 is found in high-density lipoprotein particle (GO:0034364) 20141124: node_PTN000439006 is found in blood microparticle (GO:0072562) 20141124: node_PTN000439006 is found in chylomicron (GO:0042627) 20141124: Euteleostomi_PTN000439007 is found in intermediate-density lipoprotein particle (GO:0034363) # biological_process 20141124: node_PTN000439006 participates in phospholipid efflux (GO:0033700) 20141124: node_PTN000439006 participates in cholesterol biosynthetic process (GO:0006695) 20141124: node_PTN000439006 participates in triglyceride catabolic process (GO:0019433) 20141124: node_PTN000439006 participates in positive regulation of lipid biosynthetic process (GO:0046889) 20141124: node_PTN000439006 participates in neuron projection regeneration (GO:0031102) 20141124: node_PTN000439006 participates in high-density lipoprotein particle assembly (GO:0034380) 20141124: node_PTN000439006 participates in lipoprotein metabolic process (GO:0042157) 20141124: node_PTN000439006 participates in cholesterol efflux (GO:0033344) 20141124: node_PTN000439006 participates in reverse cholesterol transport (GO:0043691) 20141124: node_PTN000439006 participates in cholesterol homeostasis (GO:0042632) 20141124: node_PTN000439006 participates in positive regulation of cholesterol esterification (GO:0010873) 20141124: node_PTN000439006 participates in regulation of cholesterol transport (GO:0032374) 20141124: node_PTN000439006 participates in very-low-density lipoprotein particle remodeling (GO:0034372) 20141124: Euteleostomi_PTN000439034 participates in phosphatidylcholine metabolic process (GO:0046470) 20141124: Euteleostomi_PTN000439034 participates in positive regulation of lipoprotein lipase activity (GO:0051006) 20141124: Euteleostomi_PTN000439034 participates in regulation of intestinal cholesterol absorption (GO:0030300) 20141124: Euteleostomi_PTN000439034 participates in positive regulation of triglyceride catabolic process (GO:0010898) 20141124: Euteleostomi_PTN000439034 participates in positive regulation of fatty acid biosynthetic process (GO:0045723) 20141124: Euteleostomi_PTN000439034 participates in triglyceride homeostasis (GO:0070328) 20141124: Euteleostomi_PTN000439007 participates in negative regulation of neuron apoptotic process (GO:0043524) 20141124: Euteleostomi_PTN000439007 participates in cholesterol catabolic process (GO:0006707) 20141124: Euteleostomi_PTN000439007 participates in lipoprotein catabolic process (GO:0042159) 20141124: Euteleostomi_PTN000439007 participates in regulation of beta-amyloid clearance (GO:1900221) 20141124: Euteleostomi_PTN000439007 participates in positive regulation of nitric-oxide synthase activity (GO:0051000) 20141124: Euteleostomi_PTN000439007 participates in regulation of axon extension (GO:0030516) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).