# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140218: Bilateria_PTN000438080 has function AMPA glutamate receptor activity (GO:0004971) 20140218: Eumetazoa_PTN001056193 has function NMDA glutamate receptor activity (GO:0004972) # cellular_component 20140218: Bilateria_PTN000438080 is found in AMPA glutamate receptor complex (GO:0032281) 20140218: Eumetazoa_PTN001056193 is found in NMDA selective glutamate receptor complex (GO:0017146) # PRUNED # biological_process 07 May 2016: node_PTN001056671 has been pruned from tree 07 May 2016: node_PTN001056343 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 26 Mar 2016: node_PTN001056343 has been pruned from tree 26 Mar 2016: node_PTN001056671 has been pruned from tree 16 Mar 2016: node_PTN001056343 has been pruned from tree 16 Mar 2016: node_PTN001056671 has been pruned from tree Arthropoda_PTN001056595 lost the glutamate receptor activity, but it should still have the receptor activity. Right now both are blank, and it is not possible to propagate receptor activity to the node. Arthropoda_PTN001056595 - stop the propagation of dendrite. In the Annotation window, it shows the NOT annotation, but in the Matrix window, the NOT (red icon with X in the middle) is not shown. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).