# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
16 Mar 2016: Updated by: TOUCHUP-v1.14
26 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150408: Deuterostomia_PTN001055383 contributes to function GABA-A receptor activity (GO:0004890) 
20150408: Bilateria_PTN000762388 has function extracellular-glutamate-gated chloride channel activity (GO:0008068) 
20150408: Eumetazoa_PTN001055382 contributes to function chloride channel activity (GO:0005254) 
20150408: Chordata_PTN001055303 contributes to function glycine binding (GO:0016594) 
20150408: Chordata_PTN001055303 contributes to function extracellular-glycine-gated chloride channel activity (GO:0016934) 
20150408: Eumetazoa_PTN001450552 has function acetylcholine binding (GO:0042166) 
20150408: Eumetazoa_PTN001450552 contributes to function acetylcholine receptor activity (GO:0015464) 
20150408: Eumetazoa_PTN001450552 contributes to function acetylcholine-activated cation-selective channel activity (GO:0004889) 
20150408: Chordata_PTN001054693 has function G-protein coupled serotonin receptor activity (GO:0004993) 
20150408: Chordata_PTN001054693 has function serotonin-activated cation-selective channel activity (GO:0005232) 
20150408: Bilateria_PTN000435002 contributes to function GABA-A receptor activity (GO:0004890) 
20150408: node_PTN001450363 contributes to function acetylcholine-activated cation-selective channel activity (GO:0004889) 
20150408: node_PTN001450363 contributes to function acetylcholine receptor activity (GO:0015464) 
20150408: node_PTN001450363 contributes to function acetylcholine binding (GO:0042166) 
20150408: Chordata_PTN001054693 has LOST/MODIFIED function acetylcholine binding (GO:0042166) 
20150408: Chordata_PTN001054693 has LOST/MODIFIED function acetylcholine receptor activity (GO:0015464) 
20150408: Chordata_PTN001054693 has LOST/MODIFIED function acetylcholine-activated cation-selective channel activity (GO:0004889) 

# cellular_component
20150408: Deuterostomia_PTN001055383 is found in GABA-A receptor complex (GO:1902711) 
20150408: Eumetazoa_PTN001450552 is found in acetylcholine-gated channel complex (GO:0005892) 
20150408: Bilateria_PTN000435002 is found in GABA-A receptor complex (GO:1902711) 
20150408: node_PTN001450363 is found in acetylcholine-gated channel complex (GO:0005892) 
20150408: Chordata_PTN001054693 is NOT found in acetylcholine-gated channel complex (GO:0005892) 

# biological_process
20150408: Chordata_PTN001055303 participates in response to amino acid (GO:0043200) 
20150408: Chordata_PTN001055303 participates in synaptic transmission, glycinergic (GO:0060012) 
20150408: Chordata_PTN001055303 participates in neuropeptide signaling pathway (GO:0007218) 
20150408: Eumetazoa_PTN001450552 participates in synaptic transmission, cholinergic (GO:0007271) 
20150408: Chordata_PTN001054693 participates in serotonin receptor signaling pathway (GO:0007210) 
20150408: node_PTN001450363 participates in neuromuscular synaptic transmission (GO:0007274) 
20150408: node_PTN001450363 participates in synaptic transmission, cholinergic (GO:0007271) 
20150408: node_PTN001450363 participates in cation transmembrane transport (GO:0098655) 
20150408: node_PTN001450363 participates in response to nicotine (GO:0035094) 
20150408: Chordata_PTN001054693 does NOT participate in synaptic transmission, cholinergic (GO:0007271) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).