# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20131112: Opisthokonta_PTN000428218 has function mRNA binding (GO:0003729) # cellular_component 20131112: Opisthokonta_PTN000428218 is found in spliceosomal complex (GO:0005681) # biological_process 20131112: Opisthokonta_PTN000428218 participates in regulation of alternative mRNA splicing, via spliceosome (GO:0000381) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES i was conservative and only annotated the opisthokontes, since the msa shows that other sequences are a bit divergent, and in particular in certain areas that are well conserved (especially in animals). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).