# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150805: root_PTN000427685 has function RNA binding (GO:0003723) # cellular_component 20150805: Eukaryota_PTN000427686 is found in catalytic step 2 spliceosome (GO:0071013) 20150805: Eukaryota_PTN000427686 is found in U2-type catalytic step 1 spliceosome (GO:0071006) 20150805: Eukaryota_PTN000427762 is found in nucleolus (GO:0005730) # biological_process 20150805: Eukaryota_PTN000427686 participates in mRNA splicing, via spliceosome (GO:0000398) 20150805: Eukaryota_PTN000427762 participates in ribosomal small subunit biogenesis (GO:0042274) 20150805: Bilateria_PTN000427765 participates in neurogenesis (GO:0022008) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).