# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function

# cellular_component
20140929: Eukaryota_PTN000427561 is found in UTP-C complex (GO:0034456) 
20140929: Eukaryota_PTN000427561 is found in CURI complex (GO:0032545) 
20140929: Eukaryota_PTN000427561 is found in small-subunit processome (GO:0032040) 

# biological_process
20140929: Eukaryota_PTN000427561 participates in tRNA export from nucleus (GO:0006409) 
20140903: Eukaryota_PTN000427561 participates in rRNA processing (GO:0006364) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family comprises the UTP22 (aka NOL6) subunits of the ribosomal Small Subunit Processome, also called the SSU Processome, a large complex which is involved in the initial cleavages of the primary rRNA transcript to separate the small ribosomal subunit (SSU) rRNA from the remainder of the transcript and the biogenesis of the small ribosomal subunit.
The SSU processome was originally identified and characterized from S. cerevisiae (Dragon et al. 2002, PMID:12068309; Gallagher et al. 2004, PMID:15489292; Bernstein et al. 2004, PMID:15590835; and reviewed in Phipps et al. 2011, PMID:21318072). As of September 2014, it has begun to be characterized experimentally from other species such as human (Turner et al. 2012, PMID:22418842; Sato et al. 2013, PMID:24219289; and Hu et al. 2011, PMID:21078665), zebrafish (Wilkins et al. 2013, PMID:24147052), and mouse (Gallenberger et al. 2011, PMID:21051332).
The UTP22 (aka NOL6) subunit is a confirmed subunit of the SSU processome, and specifically part of the UtpC subcomplex (Phipps et al. 2011, PMID:21318072).
The UTP22 (aka NOL6) subunit is also part of the CURI complex involved in tRNA export from the nucleus (PMID:23194188).
Feng et al. 2013 (PMID:24214024) performed an extensive computational analysis from 77 completely sequenced eukaryotic genomes, including representatives of the five eukaryotic supergroups: Opisthokonts, Amoebozoa, Plantae, Excavates, and Chromalveolates, and compared these to sequences from both prokaryotic and Archaeal species for all 51 confirmed and 26 likely SSU processome subunits in S. cerevisiae as indicated in Phipps et al. 2011 (PMID:21318072). In addition, Srivastava et al. have identified SSU processome subunits in the parasitic protist Entamoeba histolytica (PMID:24631428).
UTP22 (aka NOL6) is one of the 51 confirmed proteins of the S. cerevisiae SSU processome (Phipps et al. 2011, PMID:21318072)) and is highly conserved across the 77 eukaryotic species, as listed in Table 1 of Feng et al. 2013 (PMID:24214024). It is also found in the parasitic protist Entamoeba histolytica (Srivastava et al. 2014, PMID:24631428).
Annotation comments:
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No MF annotations were propagated in this tree.
There were experimental MF annotations for human NOL6 to "poly(A) RNA binding" (GO:0044822) from a high throughput study: PMID:22658674. Between the fact that these were high throughput experiments, the fact that this protein is normally part of a large complex, and the fact that it is not clear that poly(A) RNA binding is biologically relevant, I have chosen not to propagate this MF annotation.
The "RNA binding" annotation for mouse Nol6 does not appear to be supported by the paper (PMID:11895476); it appears to be derived from this statement: "The dispersion of Nrap by actinomycin D treatment mimics that of B23/nucleophosmin translocation, while the fact that this also occurs at low concentrations of actinomycin D suggests an association of Nrap with RNA polymerase I or nascent pre-rRNA."

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).