# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150817: Eukaryota_PTN000407857 has function ubiquitin protein ligase activity (GO:0061630) 

# cellular_component

# biological_process
20150817: Eukaryota_PTN000407857 participates in proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161) 
20150817: Euteleostomi_PTN000407860 participates in negative regulation of IRE1-mediated unfolded protein response (GO:1903895) 
# PRUNED

26 Mar 2016: Metazoa_PTN001814354 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
16 Mar 2016: Metazoa_PTN001814354 has been pruned from tree

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).