# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150312: Euteleostomi_PTN000405319 has function microtubule binding (GO:0008017) # cellular_component 20150312: Euteleostomi_PTN001039567 is found in extracellular space (GO:0005615) 20150312: Euteleostomi_PTN000405319 is found in microtubule bundle (GO:0097427) 20150312: Euteleostomi_PTN000405319 is found in apicolateral plasma membrane (GO:0016327) 20150312: Euteleostomi_PTN000405319 is found in lateral plasma membrane (GO:0016328) 20150312: Euteleostomi_PTN000405319 is found in spindle pole (GO:0000922) 20150312: Euteleostomi_PTN000405319 is found in midbody (GO:0030496) # biological_process 20150312: Euteleostomi_PTN001039567 participates in insulin receptor signaling pathway (GO:0008286) 20150312: Euteleostomi_PTN000405319 participates in establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197) 20150312: Euteleostomi_PTN000405319 participates in microtubule bundle formation (GO:0001578) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: It seems that we have very different functions for the sub-families. However there are just 2 different papers. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).