# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140725: node_PTN001039502 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) # cellular_component 20140725: node_PTN001039502 is found in nucleus (GO:0005634) # biological_process 20140728: node_PTN001039502 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20140728: Euteleostomi_PTN000405255 participates in cellular response to carbohydrate stimulus (GO:0071322) # PRUNED 26 Mar 2016: Embryophyta_PTN001039554 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 16 Mar 2016: Embryophyta_PTN001039554 has been pruned from tree PTN001039554 - does not have the HLH domain. - MLXIPL involved in "GO:1900402 regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter"; created annotation in Protein2GO (July 28, 2014); to propagate when available. PG 2014-07-28 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).