# HISTORY
26 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20150812: root_PTN000401752 has function phosphatidylinositol binding (GO:0035091) 
20150812: Dikarya_PTN001037916 has function actin filament binding (GO:0051015) 

# cellular_component
20150812: root_PTN000401752 is found in ruffle membrane (GO:0032587) 
20150812: Dikarya_PTN001037916 is found in actin cortical patch (GO:0030479) 

# biological_process
20150812: root_PTN000401752 participates in regulation of ruffle assembly (GO:1900027) 
20150812: Dikarya_PTN001037916 participates in actin filament bundle assembly (GO:0051017) 
20150812: Dikarya_PTN001037916 participates in actin cortical patch localization (GO:0051666) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MAF: The failure of SH3YL1 to bind F-actin suggests that it is not an evolutionarily conserved biochemical property, at least in mammalian SYLF domains. Lipid-binding is a conserved function (PMID:21624956)

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).