# HISTORY 26 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150813: Eukaryota_PTN000401295 has function RNA binding (GO:0003723) # cellular_component 20150814: Eukaryota_PTN000401295 is found in U2-type spliceosomal complex (GO:0005684) 20150814: Eukaryota_PTN000401295 is found in U2 snRNP (GO:0005686) # biological_process 20150814: Eukaryota_PTN000401295 participates in mRNA splicing, via spliceosome (GO:0000398) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family comprises a component of the U2 snRNP, called CUS2 in S. cerevisiae, and HTATSF1 in vertebrates. It binds directly to the U2 snRNA and is involved in conformational rearragments of the U2 snRNA involved in pre-spliceosome assembly. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).