# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 26 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140910: root_PTN000400405 has function RNA binding (GO:0003723) 20140910: Eukaryota_PTN000400406 has function RNA cap binding (GO:0000339) # cellular_component 20140910: root_PTN000400405 is found in nucleus (GO:0005634) 20140910: Eukaryota_PTN000400465 is found in U4/U6 x U5 tri-snRNP complex (GO:0046540) 20140910: Eukaryota_PTN000400406 is found in cytoplasmic mRNA processing body (GO:0000932) # biological_process 20140910: root_PTN000400405 participates in RNA metabolic process (GO:0016070) 20140910: Eukaryota_PTN000400465 participates in mRNA splicing, via spliceosome (GO:0000398) 20140910: Eukaryota_PTN000400406 participates in deadenylation-dependent decapping of nuclear-transcribed mRNA (GO:0000290) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).