# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140513: Eukaryota_PTN001034674 contributes to function RNA polymerase III activity (GO:0001056) 

# cellular_component
20140513: Eukaryota_PTN001034674 is found in DNA-directed RNA polymerase III complex (GO:0005666) 
20140513: Eukaryota_PTN001034674 co-localizes with nuclear chromatin (GO:0000790) 

# biological_process
20140513: Eukaryota_PTN001034674 participates in transcription initiation from RNA polymerase III promoter (GO:0006384) 
20140513: Euteleostomi_PTN000394851 participates in cell proliferation (GO:0008283) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
This family comprises a conserved subunit, referred to as RPC7, RPC31, POLR3G, or POLR3GL, of the multisubunit DNA-dependent RNA polymerase III enzyme in eukaryotes. As part of the trimeric POLR3C (RPC3)-POLR3F (RPC6)-POLR3G (RPC7) complex, it plays a role in transcription initiation complex formation (PMID:24107381).
Unusually, in the vertebrates, there is a duplication of this subunit such that there are two copies of the RPC7 subunit, referred to as POLRGL (or Polrgl) and POLR3GL (Polr3gl). Both subunits are highly conserved, with the POLR3GL subunit appearing to be more closely related to the ancestral gene thatn the POLR3G gene.  Both subunits are found in RNA polymerase III purified from cells (either one or the other, not both at the same time) and are found localized to RNAP III promoters in chromatin IP experiments, so both appear to be function. However, the regulation of the two genes differs significantly. POLR3GL is expressed constitutively at a low level and is required for cell viability. POLR3GL is not expressed in terminally differentiated cells, but is greatly upregulated in undifferentiated proliferating cells (PMID:24107381, PMID:20154270).

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).