# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150324: Eukaryota_PTN000391242 has function 3'-5' exonuclease activity (GO:0008408) # cellular_component 20150324: Eukaryota_PTN000391242 is found in checkpoint clamp complex (GO:0030896) # biological_process 20150324: Eukaryota_PTN000391242 participates in cellular response to ionizing radiation (GO:0071479) 20150324: Eukaryota_PTN000391242 participates in intra-S DNA damage checkpoint (GO:0031573) 20150324: Eukaryota_PTN000391242 participates in DNA repair (GO:0006281) 20150324: Eukaryota_PTN000391242 participates in DNA replication checkpoint (GO:0000076) 20150324: Eukaryota_PTN000391242 participates in nucleic acid phosphodiester bond hydrolysis (GO:0090305) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).