# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20160119: Euteleostomi_PTN000390479 has function growth factor activity (GO:0008083) 20160119: Euteleostomi_PTN000390479 has function ciliary neurotrophic factor receptor binding (GO:0005127) 20160119: Euteleostomi_PTN000390479 has function cytokine activity (GO:0005125) # cellular_component 20160119: Euteleostomi_PTN000390479 is found in axon (GO:0030424) 20160119: Euteleostomi_PTN000390479 is found in extracellular space (GO:0005615) # biological_process 20160119: Euteleostomi_PTN000390479 participates in positive regulation of cell proliferation (GO:0008284) 20160119: Euteleostomi_PTN000390479 participates in positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) 20160119: Euteleostomi_PTN000390479 participates in ciliary neurotrophic factor-mediated signaling pathway (GO:0070120) 20160119: Euteleostomi_PTN000390479 participates in negative regulation of neuron apoptotic process (GO:0043524) 20160119: Euteleostomi_PTN000390479 participates in positive regulation of axon regeneration (GO:0048680) 20160119: Euteleostomi_PTN000390479 participates in astrocyte activation (GO:0048143) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).