# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140508: Opisthokonta_PTN000389117 has function GTPase regulator activity (GO:0030695) 

# cellular_component
20140508: Opisthokonta_PTN000389117 is found in TSC1-TSC2 complex (GO:0033596) 

# biological_process
20140508: Opisthokonta_PTN000389117 participates in regulation of cell cycle (GO:0051726) 
20140508: Opisthokonta_PTN000389117 participates in regulation of actin cytoskeleton organization (GO:0032956) 
20140508: Opisthokonta_PTN000389117 participates in negative regulation of insulin receptor signaling pathway (GO:0046627) 
20140508: Opisthokonta_PTN000389117 participates in regulation of GTPase activity (GO:0043087) 
20140508: Opisthokonta_PTN000389117 participates in negative regulation of TOR signaling (GO:0032007) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Made annotations similar to the other member of the complex TSC2 (PTHR10063)
Could not annotate  'GO:0051898 negative regulation of protein kinase B signaling' and 'GO:0030178 negative regulation of Wnt signaling pathway'  because there are no primary annotations.
Annotated family PG 2014-25-08

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).