# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150116: Theria _PTN000389093 has function receptor binding (GO:0005102) # cellular_component 20150116: Theria _PTN000389093 is found in plasma membrane (GO:0005886) 20150116: Theria _PTN000389093 is found in extracellular exosome (GO:0070062) # biological_process 20150116: Theria _PTN000389093 participates in cell-cell signaling (GO:0007267) 20150116: Theria _PTN000389093 participates in signal transduction (GO:0007165) 20150116: Theria _PTN000389093 participates in cell proliferation (GO:0008283) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).