# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20150318: Eukaryota_PTN000388839 is found in elongin complex (GO:0070449) # biological_process 20150318: Eukaryota_PTN000388839 participates in transcription elongation from RNA polymerase II promoter (GO:0006368) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES The elongin complex is composed of a transcriptionally active A subunit and two regulatory subunits, B and C (PMID:22649776). PTHR15141 corresponds to Elongin A. The ubiquitin-dependent proteolysis occurs specifically in response to DNA damage, see PMID:19037258 (mammalian cells) and PMID: 17296727 (yeast). Annotated PG 2015-03-19 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).