# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
16 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140729: root_PTN000387569 has function N-acylglucosamine 2-epimerase activity (GO:0050121) 
20140728: Euteleostomi_PTN000387572 has function endopeptidase inhibitor activity (GO:0004866) 
20140729: Proteobacteria_PTN001431668 has LOST/MODIFIED function N-acylglucosamine 2-epimerase activity (GO:0050121) 

# cellular_component

# biological_process
20140729: root_PTN000387569 participates in N-acetylglucosamine metabolic process (GO:0006044) 
20140729: Proteobacteria_PTN001431668 does NOT participate in N-acetylglucosamine metabolic process (GO:0006044) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Two clades: bacterial and animal, no apparent horizontal transfer but few bacteria so hard to know for sure
Highly conserved except for three bacterial sequences: ECOLI, BRAJA, DICTD
MF
propagated catalytic activity to root because of wide taxonomic distribution of substrate (see wikipedia), but loss in divergent clades as definitely a divergent function annotated in E. coli
propagated renin inhibitor to base of vertebrates as that is where renin evolved (see RENIN (PTHR13683:SF77))
CC
did not propagate exosome because MF and BP not clearly related
BP
propagated processes based on taxonomic distribution:
http://biocyc.org/META/NEW-IMAGE?type=COMPOUND&object=N-ACETYLNEURAMINATE says "N-acetylneuraminate, the most ubiquitous species amongst the sialic acids, is widely distributed in the animal kingdom as a component of oligosaccharides, glycoproteins, and glycolipids."
did not propagate regulation of blood pressure (TAS, plus no apparent evidence)
did not propagate molecular regulation processes as redundant with MF

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).