# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140815: Eukaryota_PTN000387090 has function ubiquitin binding (GO:0043130) 20140815: Eukaryota_PTN000387090 has function identical protein binding (GO:0042802) # cellular_component 20140815: Eukaryota_PTN000387090 is found in autophagosome (GO:0005776) 20140815: Eukaryota_PTN000387090 is found in aggresome (GO:0016235) # biological_process 20140815: Eukaryota_PTN000387090 participates in positive regulation of macroautophagy (GO:0016239) 20140815: Eukaryota_PTN000387090 participates in ubiquitin-dependent protein catabolic process (GO:0006511) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures)= aggrephagy ?. Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).