# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process # PRUNED 25 Mar 2016: node_PTN001431438 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 16 Mar 2016: node_PTN001431438 has been pruned from tree MF - There are contradictory annotations. Human NPAT was annotated as both "sequence specific DNA binding transcription factor" and "transcription cofactor". According to GO definition, transcrition cofactor does not bind to DNA. Therefore, these two annotations contradict to each other. No MF terms were propagated. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).