# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150327: Eukaryota_PTN000386636 has function DNA binding (GO:0003677) 20150327: Euteleostomi_PTN000424568 has function methyl-CpG binding (GO:0008327) 20150327: Euteleostomi_PTN000424568 has function double-stranded methylated DNA binding (GO:0010385) # cellular_component 20150327: node_PTN001431162 is found in nucleus (GO:0005634) 20150327: node_PTN001431162 is found in chromatin (GO:0000785) 20150327: Euteleostomi_PTN000424568 is found in heterochromatin (GO:0000792) 20150327: Euteleostomi_PTN000424568 is found in cytosol (GO:0005829) # biological_process 20150327: Eukaryota_PTN000386636 participates in response to radiation (GO:0009314) 20150327: Euteleostomi_PTN000424568 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20150327: Euteleostomi_PTN000424568 participates in locomotory behavior (GO:0007626) 20150327: Euteleostomi_PTN000386639 participates in DNA repair (GO:0006281) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).