# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140911: Euteleostomi_PTN000385094 has function hormone activity (GO:0005179) # cellular_component 20140911: Euteleostomi_PTN000385094 is found in extracellular space (GO:0005615) # biological_process 20140911: Euteleostomi_PTN000385094 participates in cell-cell signaling (GO:0007267) 20140911: Amniota_PTN000385095 participates in urogenital system development (GO:0001655) 20140911: Amniota_PTN000385095 participates in Mullerian duct regression (GO:0001880) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES - Mullerian ducts exist in birds and fish, see http://www.ucumberlands.edu/academics/biology/faculty/kuss/courses/Urogenital/ComparativeUGAnatomy.htm, but not in teleost fish, see PubMed: 21750047, so I propagated the process to the birds. Disputes - RGD P49000 Amh GO:0001541 ovarian follicle development IDA PMID:16720622; AMH inhibits ovarian follicle development; so it could be annotated to 'negative regulation of ovarian follicle development'. (Dispute ID 1433; Fixed 2014-09-12). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).