# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20141204: Eukaryota_PTN000383724 has function RNA binding (GO:0003723) 20141204: Eukaryota_PTN000383724 has function ribonuclease III activity (GO:0004525) 20141204: Eumetazoa_PTN001029377 has function deoxyribonuclease I activity (GO:0004530) # cellular_component 20141204: Eukaryota_PTN000383724 is found in cytoplasm (GO:0005737) 20141204: Eukaryota_PTN000383724 is found in nucleus (GO:0005634) 20141204: Eukaryota_PTN000383724 is found in RISC complex (GO:0016442) # biological_process 20141204: Eukaryota_PTN000383724 participates in production of siRNA involved in RNA interference (GO:0030422) 20141204: Eumetazoa_PTN001029377 participates in apoptotic DNA fragmentation (GO:0006309) 20141204: Eumetazoa_PTN001029377 participates in pre-miRNA processing (GO:0031054) 20141204: Diptera_PTN000383764 does NOT participate in pre-miRNA processing (GO:0031054) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Dicer ribonuclease is converted into a death-promoting deoxyribonuclease in a caspase dependent manner (ar least in animals). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).