# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140815: Euteleostomi_PTN001025958 has function protein kinase A binding (GO:0051018) 20140815: Euteleostomi_PTN001025958 has function ion channel binding (GO:0044325) # cellular_component 20140815: Euteleostomi_PTN000376569 is found in centrosome (GO:0005813) 20140815: Euteleostomi_PTN001025958 is found in perinuclear region of cytoplasm (GO:0048471) 20140815: Euteleostomi_PTN001025958 is found in sarcoplasmic reticulum (GO:0016529) # biological_process 20140815: Euteleostomi_PTN000376569 participates in centriole-centriole cohesion (GO:0010457) 20140815: Euteleostomi_PTN001025958 participates in intracellular signal transduction (GO:0035556) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).