# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component 20160113: Eukaryota_PTN000375798 is found in nuclear pore (GO:0005643) # biological_process 20160113: Eukaryota_PTN000375798 participates in nucleocytoplasmic transport (GO:0006913) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains the Aladin proteins which are characterized as being part of the cytoplasmic filaments of the nuclear pore complex (NPC). The Aladin protein is found in human, and many other animals, as well as plants, but does not appear to have an equivalent in fungi. Although the annotated human gene (AAAS) has a "colocalizes with" qualifier associated with the annotation to the CC term "nuclear pore", I have chosen not to propagate the qualifier because Hoelz et al. in their 2011 Annual Review of Biochemistry on "The Structure of the Nuclear Pore complex" (PMID:21495847) include Aladin as a known component of the NPC. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).