# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160428: Bacteria _PTN001801640 has function heparan sulfate proteoglycan binding (GO:0043395) 20160428: Bacteria _PTN001801640 has function beta-glucuronidase activity (GO:0004566) 20160428: Bacteria _PTN001801640 has function heparanase activity (GO:0030305) 20160428: Euteleostomi_PTN000372554 has LOST/MODIFIED function beta-glucuronidase activity (GO:0004566) 20160428: Euteleostomi_PTN000372554 has LOST/MODIFIED function heparanase activity (GO:0030305) # cellular_component 20160428: Opisthokonta_PTN001024080 is found in proteinaceous extracellular matrix (GO:0005578) 20160428: Opisthokonta_PTN001024080 is found in intracellular (GO:0005622) 20160428: Embryophyta_PTN001024111 is found in plant-type cell wall (GO:0009505) # biological_process 20160428: Bacteria _PTN001801640 participates in heparan sulfate proteoglycan catabolic process (GO:0030200) 20160428: Bacteria _PTN001801640 participates in extracellular matrix organization (GO:0030198) 20160428: Euteleostomi_PTN000372531 participates in cell-matrix adhesion (GO:0007160) 20160428: Euteleostomi_PTN000372531 participates in angiogenesis involved in wound healing (GO:0060055) 20160428: Euteleostomi_PTN000372554 does NOT participate in heparan sulfate proteoglycan catabolic process (GO:0030200) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).