# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150220: root_PTN000369696 has function ferric-chelate reductase (NADPH) activity (GO:0052851) 20150220: root_PTN000369696 has function cupric reductase activity (GO:0008823) 20150220: Amniota_PTN000369702 has LOST/MODIFIED function ferric-chelate reductase (NADPH) activity (GO:0052851) 20150220: Amniota_PTN000369702 has LOST/MODIFIED function cupric reductase activity (GO:0008823) # cellular_component 20150220: root_PTN000369696 is found in endosome (GO:0005768) 20150220: root_PTN000369696 is found in integral component of plasma membrane (GO:0005887) 20150220: Bacteria _PTN001800628 is NOT found in endosome (GO:0005768) 20150220: Bacteria _PTN001800624 is NOT found in endosome (GO:0005768) 20150220: Bacteria _PTN000369802 is NOT found in endosome (GO:0005768) 20150220: Euryarchaeota_PTN001022989 is NOT found in endosome (GO:0005768) # biological_process 20150220: root_PTN000369696 participates in ferric iron import into cell (GO:0097461) 20150220: root_PTN000369696 participates in copper ion import (GO:0015677) 20150220: Amniota_PTN000369702 does NOT participate in ferric iron import into cell (GO:0097461) 20150220: Amniota_PTN000369702 does NOT participate in copper ion import (GO:0015677) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).