# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150723: Theria _PTN000369187 has function high-density lipoprotein particle receptor binding (GO:0070653) 20150723: Theria _PTN000369187 has function lipase inhibitor activity (GO:0055102) 20150723: Theria _PTN000369187 has function phospholipid binding (GO:0005543) # cellular_component 20150723: Theria _PTN000369187 is found in very-low-density lipoprotein particle (GO:0034361) 20150723: Theria _PTN000369187 is found in spherical high-density lipoprotein particle (GO:0034366) 20150723: Theria _PTN000369187 is found in chylomicron (GO:0042627) 20150723: Theria _PTN000369187 is found in intermediate-density lipoprotein particle (GO:0034363) # biological_process 20150723: Theria _PTN000369187 participates in negative regulation of triglyceride catabolic process (GO:0010897) 20150723: Theria _PTN000369187 participates in negative regulation of high-density lipoprotein particle clearance (GO:0010987) 20150723: Theria _PTN000369187 participates in negative regulation of lipoprotein lipase activity (GO:0051005) 20150723: Theria _PTN000369187 participates in negative regulation of very-low-density lipoprotein particle clearance (GO:0010916) 20150723: Theria _PTN000369187 participates in triglyceride homeostasis (GO:0070328) 20150723: Theria _PTN000369187 participates in lipid transport (GO:0006869) 20150723: Theria _PTN000369187 participates in cholesterol homeostasis (GO:0042632) 20150723: Theria _PTN000369187 participates in negative regulation of low-density lipoprotein particle clearance (GO:0010989) 20150723: Theria _PTN000369187 participates in very-low-density lipoprotein particle assembly (GO:0034379) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).