# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150320: Eukaryota_PTN000365142 has function ubiquitin protein ligase activity (GO:0061630) # cellular_component 20150320: Eukaryota_PTN000365142 is found in nuclear heterochromatin (GO:0005720) # biological_process 20150320: Eukaryota_PTN000365142 participates in maintenance of DNA methylation (GO:0010216) 20150320: Eukaryota_PTN000365142 participates in regulation of methylation-dependent chromatin silencing (GO:0090308) 20150320: Eukaryota_PTN000365142 participates in protein ubiquitination (GO:0016567) 20150320: Euteleostomi_PTN000365172 participates in histone monoubiquitination (GO:0010390) # PRUNED 07 May 2016: Bilateria_PTN001020486 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 25 Mar 2016: Bilateria_PTN001020486 has been pruned from tree 16 Mar 2016: Bilateria_PTN001020486 has been pruned from tree Did not propagate 'protein ubiquitination involved in ubiquitin-dependent protein catabolic process' since this is from a single paper, where UHRF1 targets a protein in lekemic cells (PMID:22945642) Disputed HGNC protein Q96PU4 GO:0006511 (ubiquitin-dependent protein catabolic process) IDA ECO:0000314 PMID:14741369 Annotated PG 2015-03-20 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).