# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
16 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150320: Eukaryota_PTN000365142 has function ubiquitin protein ligase activity (GO:0061630) 

# cellular_component
20150320: Eukaryota_PTN000365142 is found in nuclear heterochromatin (GO:0005720) 

# biological_process
20150320: Eukaryota_PTN000365142 participates in maintenance of DNA methylation (GO:0010216) 
20150320: Eukaryota_PTN000365142 participates in regulation of methylation-dependent chromatin silencing (GO:0090308) 
20150320: Eukaryota_PTN000365142 participates in protein ubiquitination (GO:0016567) 
20150320: Euteleostomi_PTN000365172 participates in histone monoubiquitination (GO:0010390) 
# PRUNED

07 May 2016: Bilateria_PTN001020486 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
25 Mar 2016: Bilateria_PTN001020486 has been pruned from tree
16 Mar 2016: Bilateria_PTN001020486 has been pruned from tree
Did not propagate 'protein ubiquitination involved in ubiquitin-dependent protein catabolic process' since this is from a single paper, where UHRF1 targets a protein in lekemic cells (PMID:22945642)
Disputed HGNC	protein	Q96PU4	GO:0006511	(ubiquitin-dependent protein catabolic process) IDA	ECO:0000314	PMID:14741369
Annotated PG 2015-03-20

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).