# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150312: Euteleostomi_PTN000363866 has function SH3/SH2 adaptor activity (GO:0005070) 20150312: Euteleostomi_PTN000363866 has function transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) 20150312: Ornithorhynchus anatinus_F6VL77 has LOST/MODIFIED function SH3/SH2 adaptor activity (GO:0005070) 20150312: Ornithorhynchus anatinus_F6VL77 has LOST/MODIFIED function transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) 20150312: Ornithorhynchus anatinus_K7EB55 has LOST/MODIFIED function SH3/SH2 adaptor activity (GO:0005070) 20150312: Ornithorhynchus anatinus_K7EB55 has LOST/MODIFIED function transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) 20150312: Equus caballus_F6ULP6 has LOST/MODIFIED function SH3/SH2 adaptor activity (GO:0005070) 20150312: Equus caballus_F6ULP6 has LOST/MODIFIED function transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068) # cellular_component 20150312: Euteleostomi_PTN000363866 is found in cytoplasm (GO:0005737) 20150312: Ornithorhynchus anatinus_F6VL77 is NOT found in cytoplasm (GO:0005737) 20150312: Ornithorhynchus anatinus_K7EB55 is NOT found in cytoplasm (GO:0005737) 20150312: Equus caballus_F6ULP6 is NOT found in cytoplasm (GO:0005737) # biological_process 20150312: Bilateria_PTN001019935 participates in immune response (GO:0006955) 20150312: Bilateria_PTN001019935 participates in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20150312: Bilateria_PTN001019935 participates in intracellular signal transduction (GO:0035556) 20150312: Ornithorhynchus anatinus_F6VL77 does NOT participate in immune response (GO:0006955) 20150312: Ornithorhynchus anatinus_F6VL77 does NOT participate in intracellular signal transduction (GO:0035556) 20150312: Ornithorhynchus anatinus_F6VL77 does NOT participate in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20150312: Ornithorhynchus anatinus_K7EB55 does NOT participate in immune response (GO:0006955) 20150312: Ornithorhynchus anatinus_K7EB55 does NOT participate in intracellular signal transduction (GO:0035556) 20150312: Ornithorhynchus anatinus_K7EB55 does NOT participate in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20150312: Danio rerio_E7FEX6 does NOT participate in immune response (GO:0006955) 20150312: Danio rerio_E7FEX6 does NOT participate in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20150312: Danio rerio_E7FEX6 does NOT participate in intracellular signal transduction (GO:0035556) 20150312: Equus caballus_F6ULP6 does NOT participate in immune response (GO:0006955) 20150312: Equus caballus_F6ULP6 does NOT participate in intracellular signal transduction (GO:0035556) 20150312: Equus caballus_F6ULP6 does NOT participate in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).