# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 16 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140903: Eumetazoa_PTN001019240 has function beta-amyloid binding (GO:0001540) 20140903: Eumetazoa_PTN001019240 has function transcription factor binding (GO:0008134) # cellular_component 20140903: Eumetazoa_PTN001019240 is found in cytoplasm (GO:0005737) 20140903: Eumetazoa_PTN001019240 is found in nucleus (GO:0005634) # biological_process 20140903: Eumetazoa_PTN001019240 participates in regulation of transcription, DNA-templated (GO:0006355) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MAF: Beta-amyloid-binding shown in different species in different studies. For BPs, would not propagate more than regulation of transcription. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).