# HISTORY 08 Aug 2016: Saved by pascalegaudet using Paint 2.22 # molecular_function # cellular_component 20160808: root_PTN000360956 is found in mitochondrial inner membrane (GO:0005743) # biological_process 20160808: Eukaryota_PTN000360953 participates in cellular metal ion homeostasis (GO:0006875) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Did not annotate the antiporter function because there is evidence that this protein is a regulator of the transporter, and may not have antiporter activity (see for example PMID 24898248). PG 2016-08-08 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).