# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 18 Nov 2015: redistribution of PTN001400465 from PTHR12796 to PTHR13992 16 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150209: Eukaryota_PTN001400465 has function RNA polymerase II transcription cofactor activity (GO:0001104) 20150709: Opisthokonta_PTN001795839 has function RNA polymerase II transcription coactivator activity (GO:0001105) 20150709: Bilateria_PTN000360523 has function transcription factor binding (GO:0008134) 20150709: Bilateria_PTN000360523 has function transcription corepressor activity (GO:0003714) 20150709: Bilateria_PTN000360523 has function ligand-dependent nuclear receptor binding (GO:0016922) 20150709: Euteleostomi_PTN000750240 has function thyroid hormone receptor binding (GO:0046966) # cellular_component 20150209: Eukaryota_PTN001400465 is found in mediator complex (GO:0016592) 20150709: Ascomycota_PTN000360593 is found in Set3 complex (GO:0034967) 20150709: Bilateria_PTN000360523 is found in histone deacetylase complex (GO:0000118) 20150709: Euteleostomi_PTN000750240 is found in Sin3 complex (GO:0016580) # biological_process 20150209: Eukaryota_PTN001400465 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20150709: Dikarya_PTN001018327 participates in histone deacetylation (GO:0016575) 20150709: Bilateria_PTN000360523 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).