# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
16 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function

# cellular_component

# biological_process
20140311: Bilateria_PTN000359601 participates in apoptotic DNA fragmentation (GO:0006309) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
Primary annotations could be more granular: some members of this family have both endo and exonuclease activity, some act on single-stranded substrates, EXOG seems to be able to trigger apoptosis by imparing mtDNA integrity (PMID: 21768646), etc.
PG 2014-03-11
I took a quick look at the family in PAINT.  I think the family needs to have quite a few
the alignment is the BIR domain, but there are quite a few sequences (one vertebrate clade and many of the plant sequences) that don't align well to that region, so they don¹t belong in the family.  They were probably brought into the family because one of the BIR domain-containing proteins also has a ubiquitin ligase domain, so other ubq-ligases match it.  I'd suggest that we prune out these non-BIR-domain-containing sequences, rebuild the tree and then annotate.  I went through the tree and pruned out the clades or individual sequences that didn't align (see attached file), maybe Huaiyu or Sagar can remove these sequences and rebuild.  What do you think?
Paul T  2014-03-11

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).