# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150807: root_PTN000359236 has function mRNA binding (GO:0003729) 20150807: root_PTN000359236 has function snRNA binding (GO:0017069) 20150807: Eukaryota_PTN000359237 has function U1 snRNA binding (GO:0030619) # cellular_component 20150807: root_PTN000359236 is found in precatalytic spliceosome (GO:0071011) 20150807: root_PTN000359236 is found in commitment complex (GO:0000243) 20150807: Eukaryota_PTN000359296 is found in U12-type spliceosomal complex (GO:0005689) 20150807: Eukaryota_PTN000359237 is found in U1 snRNP (GO:0005685) 20150807: Eukaryota_PTN000359237 is found in U2-type prespliceosome (GO:0071004) # biological_process 20150807: root_PTN000359236 participates in mRNA splicing, via spliceosome (GO:0000398) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains the U1 small nuclear ribonucleoprotein 70 kDa subunit of the U1 snRNP (encoded by the SNRNP70 gene in vertebrates and the SNP1 gene in S. cerevisiae) and the equivalent subunit of the U11 snRNP for the minor splicesosome (encoded by the SNRNP35 gene in vertebrates; note that S. cerevisiae has lost the minor spliceosome. The U1 snRNP is one the first snRNP to assemble onto the pre-mRNA, recognizing the 5' splice site (Wahl et al. 2009 PMID:19239890). U11 is considered to be the equivalent of U1 for the minor spliceosome. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).