# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20160107: Eukaryota_PTN000358347 contributes to function transcription factor activity, sequence-specific DNA binding (GO:0003700) 20160107: Eukaryota_PTN000358347 has function RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) # cellular_component 20160107: Eukaryota_PTN000358347 is found in RNA polymerase II transcription factor complex (GO:0090575) # biological_process 20160107: Eukaryota_PTN000358347 participates in regulation of transcription from RNA polymerase II promoter (GO:0006357) 20160107: node_PTN000358354 participates in regulation of neurogenesis (GO:0050767) 20160107: Magnoliophyta_PTN000358475 participates in iron ion homeostasis (GO:0055072) 20160107: Magnoliophyta_PTN000358475 participates in cellular response to iron ion starvation (GO:0010106) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).