# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 15 Mar 2016: Updated by: TOUCHUP-v1.14 25 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20160301: Eukaryota_PTN000357044 has function protein serine/threonine kinase activity (GO:0004674) 20160301: Arabidopsis thaliana_locus:2042551 has LOST/MODIFIED function protein serine/threonine kinase activity (GO:0004674) 20160301: Magnoliophyta_PTN001794340 has LOST/MODIFIED function protein serine/threonine kinase activity (GO:0004674) # cellular_component 20160301: Eukaryota_PTN000357044 is found in cytosol (GO:0005829) 20160301: Bilateria_PTN000357046 is found in endomembrane system (GO:0012505) 20160301: Arabidopsis thaliana_locus:2042551 is NOT found in cytosol (GO:0005829) 20160301: Magnoliophyta_PTN001794340 is NOT found in cytosol (GO:0005829) # biological_process 20160301: Eukaryota_PTN000357044 participates in protein phosphorylation (GO:0006468) 20160301: Eukaryota_PTN000357044 participates in intracellular signal transduction (GO:0035556) 20160301: Bilateria_PTN000357046 participates in ER to Golgi vesicle-mediated transport (GO:0006888) 20160301: Metazoa_PTN001794151 participates in positive regulation of ion transmembrane transporter activity (GO:0032414) 20160301: Metazoa_PTN001794151 participates in regulation of ion homeostasis (GO:2000021) 20160301: Euteleostomi_PTN000357195 participates in positive regulation of calcium ion transport (GO:0051928) 20160301: Euteleostomi_PTN000357221 participates in positive regulation of sodium ion transmembrane transporter activity (GO:2000651) 20160301: Tetrapoda_PTN001016448 participates in renal sodium ion absorption (GO:0070294) 20160301: Magnoliophyta_PTN000357284 participates in regulation of transcription, DNA-templated (GO:0006355) 20160301: Magnoliophyta_PTN001794340 participates in regulation of transcription, DNA-templated (GO:0006355) 20160301: Arabidopsis thaliana_locus:2042551 does NOT participate in protein phosphorylation (GO:0006468) 20160301: Arabidopsis thaliana_locus:2042551 does NOT participate in intracellular signal transduction (GO:0035556) 20160301: Magnoliophyta_PTN001794340 does NOT participate in protein phosphorylation (GO:0006468) 20160301: Magnoliophyta_PTN001794340 does NOT participate in intracellular signal transduction (GO:0035556) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).