# HISTORY
25 Mar 2016: Updated by: TOUCHUP-v1.15
15 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20151021: root_PTN000352258 has function endopeptidase inhibitor activity (GO:0004866) 
20151021: Euteleostomi_PTN001790518 has function cysteine-type endopeptidase inhibitor activity (GO:0004869) 
20151021: Amniota_PTN001418583 has function serine-type endopeptidase inhibitor activity (GO:0004867) 
20151021: Amniota_PTN001418583 has function heparin binding (GO:0008201) 
20151021: Amniota_PTN001418583 has function zinc ion binding (GO:0008270) 
20151021: Amniota_PTN000352290 has function metalloendopeptidase inhibitor activity (GO:0008191) 

# cellular_component
20151021: root_PTN000352258 is found in extracellular region (GO:0005576) 
20151021: Euteleostomi_PTN001790518 is found in blood microparticle (GO:0072562) 
20151021: Euteleostomi_PTN000352259 is found in blood microparticle (GO:0072562) 
20151021: Euteleostomi_PTN000352259 is found in extracellular matrix (GO:0031012) 
20151021: Amniota_PTN001418583 is found in endolysosome (GO:0036019) 
20151021: Amniota_PTN001418583 is found in blood microparticle (GO:0072562) 

# biological_process
20151021: Euteleostomi_PTN001790518 participates in positive regulation of cytosolic calcium ion concentration (GO:0007204) 
20151021: Euteleostomi_PTN001790518 participates in negative regulation of blood coagulation (GO:0030195) 
20151021: Euteleostomi_PTN000352259 participates in negative regulation of biomineral tissue development (GO:0070168) 
20151021: Amniota_PTN001418583 participates in regulation of platelet activation (GO:0010543) 
20151021: Amniota_PTN001418583 participates in heme transport (GO:0015886) 
20151021: Amniota_PTN001418583 participates in negative regulation of fibrinolysis (GO:0051918) 
20151021: Amniota_PTN000352290 participates in binding of sperm to zona pellucida (GO:0007339) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).