# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140728: root_PTN000350180 has function monooxygenase activity (GO:0004497) 20140728: Eukaryota_PTN000350492 has function kynurenine 3-monooxygenase activity (GO:0004502) 20140728: Eukaryota_PTN000350492 has function flavin adenine dinucleotide binding (GO:0050660) 20140728: Eukaryota_PTN000350492 has function NAD(P)H oxidase activity (GO:0016174) # cellular_component 20140728: Opisthokonta_PTN000350184 is found in mitochondrion (GO:0005739) # biological_process 20140728: root_PTN000350180 participates in secondary metabolite biosynthetic process (GO:0044550) 20140728: Dikarya_PTN001012612 participates in cellular response to drug (GO:0035690) 20140728: Opisthokonta_PTN000350493 participates in NAD metabolic process (GO:0019674) 20140728: Opisthokonta_PTN000350493 participates in kynurenine metabolic process (GO:0070189) 20140728: node_PTN000350181 participates in ubiquinone biosynthetic process (GO:0006744) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20140728: root_PTN000350180 to response to stress (GO:0006950) is an excluded term and not to be used for annotation # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).