# HISTORY 10 Aug 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20160810: Metazoa_PTN001787738 has function ryanodine-sensitive calcium-release channel activity (GO:0005219) 20160810: Metazoa_PTN001787753 has function inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity (GO:0005220) 20160810: Metazoa_PTN001787738 has function calcium-induced calcium release activity (GO:0048763) 20160810: root_PTN001416417 has function calcium ion binding (GO:0005509) 20160810: Metazoa_PTN001787753 has function inositol 1,4,5 trisphosphate binding (GO:0070679) 20160810: Metazoa_PTN001787753 has function phosphatidylinositol binding (GO:0035091) # cellular_component 20160810: Metazoa_PTN001787738 is found in sarcoplasmic reticulum (GO:0016529) 20160810: Metazoa_PTN001787738 is found in sarcoplasmic reticulum membrane (GO:0033017) 20160810: Metazoa_PTN001787738 is found in I band (GO:0031674) 20160810: Metazoa_PTN001787738 is found in smooth endoplasmic reticulum (GO:0005790) 20160810: Metazoa_PTN001787738 is found in Z disc (GO:0030018) 20160810: Metazoa_PTN001787738 is found in calcium channel complex (GO:0034704) 20160810: Metazoa_PTN001787738 is found in sarcolemma (GO:0042383) 20160810: Metazoa_PTN001787753 is found in endoplasmic reticulum membrane (GO:0005789) 20160810: Metazoa_PTN001787753 is found in sarcoplasmic reticulum (GO:0016529) 20160810: Metazoa_PTN001787753 is found in secretory granule membrane (GO:0030667) 20160810: root_PTN001416417 is found in plasma membrane (GO:0005886) 20160810: Eukaryota_PTN001787768 is found in cytoplasmic vesicle membrane (GO:0030659) # biological_process 20160810: root_PTN001416417 participates in release of sequestered calcium ion into cytosol (GO:0051209) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).