# HISTORY
07 May 2016: Updated by: TOUCHUP-v1.18
15 Mar 2016: Updated by: TOUCHUP-v1.14
25 Mar 2016: Updated by: TOUCHUP-v1.15

# molecular_function
20150320: root_PTN000342793 has function aspartic-type endopeptidase activity (GO:0004190) 
20150320: node_PTN000343246 has function beta-amyloid binding (GO:0001540) 

# cellular_component
20150320: Tetrapoda_PTN000342963 is found in endosome (GO:0005768) 
20150320: saccharomyceta_PTN000343128 is found in fungal-type vacuole (GO:0000324) 
20150320: Opisthokonta_PTN001007735 is found in extracellular space (GO:0005615) 
20150320: Opisthokonta_PTN001007735 is found in lysosome (GO:0005764) 
20150320: Euteleostomi_PTN001415104 is found in alveolar lamellar body (GO:0097208) 
20150320: Eukaryota_PTN001008040 is found in food vacuole (GO:0020020) 
20150320: node_PTN000343246 is found in Golgi apparatus (GO:0005794) 
20150320: Stramenopiles_PTN001008053 is NOT found in food vacuole (GO:0020020) 

# biological_process
20150320: root_PTN000342793 participates in protein catabolic process (GO:0030163) 
20150320: root_PTN000342793 participates in proteolysis (GO:0006508) 
20150320: saccharomyceta_PTN000343128 participates in proteolysis involved in cellular protein catabolic process (GO:0051603) 
20150320: Euteleostomi_PTN001415123 participates in autophagy (GO:0006914) 
20150320: Euteleostomi_PTN000342884 participates in angiotensin maturation (GO:0002003) 
20150320: node_PTN000343246 participates in membrane protein ectodomain proteolysis (GO:0006509) 
20150320: node_PTN000343246 participates in beta-amyloid metabolic process (GO:0050435) 
20150320: Euteleostomi_PTN000342884 does NOT participate in protein catabolic process (GO:0030163) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).