# HISTORY 29 Apr 2016: Saved by krc using Paint 2.0-beta17 28 Apr 2016: Saved by krc using Paint 2.0-beta17 # molecular_function 20160428: Eukaryota_PTN000334066 has function structural constituent of nuclear pore (GO:0017056) 20160428: Eukaryota_PTN000334066 has function nucleocytoplasmic transporter activity (GO:0005487) # cellular_component 20160428: Eukaryota_PTN000334066 is found in nuclear pore outer ring (GO:0031080) 20160428: Eukaryota_PTN000334066 co-localizes with condensed chromosome kinetochore (GO:0000777) # biological_process 20160428: Eukaryota_PTN000334066 participates in protein import into nucleus (GO:0006606) 20160428: Eukaryota_PTN000334066 participates in RNA export from nucleus (GO:0006405) 20160428: Eukaryota_PTN000334066 participates in chromatin organization (GO:0006325) 20160428: Eukaryota_PTN000334066 participates in regulation of transcription, DNA-templated (GO:0006355) 20160428: Eukaryota_PTN000334066 participates in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery (GO:0000972) 20160428: Eukaryota_PTN000334066 participates in nuclear pore distribution (GO:0031081) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains a conserved outer ring nucleoporin, called NUP133 in S. cerevisiae, vertebrates, and most other species. There is a body of evidence that a number of nuclear pore complex components are also involved in regulation of mitosis: - Forbes DJ, Travesa A, Nord MS, Bernis C. Nuclear transport factors: global regulation of mitosis. Curr Opin Cell Biol. 2015 Aug;35:78-90. Review. (PMID:25982429) # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).